{"id":5045,"date":"2016-07-12T12:56:56","date_gmt":"2016-07-12T11:56:56","guid":{"rendered":"https:\/\/perruchenautomne.eu\/wordpress\/?p=5045"},"modified":"2016-07-30T09:53:36","modified_gmt":"2016-07-30T08:53:36","slug":"jinarc-tolvaptan-officiellement-accessible-en-france","status":"publish","type":"post","link":"https:\/\/perruchenautomne.eu\/wordpress\/2016\/07\/12\/jinarc-tolvaptan-officiellement-accessible-en-france\/","title":{"rendered":"Jinarc (Tolvaptan) officiellement accessible en France"},"content":{"rendered":"<p>\u00c7a y est le premier traitement ralentissant la progression de la polykystose r\u00e9nale autosomique dominante est disponible en France. L&rsquo;arr\u00eat\u00e9 vient <a href=\"https:\/\/www.legifrance.gouv.fr\/affichTexte.do;jsessionid=FDFFB2F953CB9684B0BBD87E46468F3F.tpdila18v_2?cidTexte=JORFTEXT000032879105&amp;dateTexte=&amp;oldAction=rechJO&amp;categorieLien=id&amp;idJO=JORFCONT000032878899\">d&rsquo;\u00eatre publi\u00e9 au JO<\/a>.<\/p>\n<p>Nous pourrons le prescrire d&rsquo;ici 4 jours. Il y a quelques contraintes. Le m\u00e9decin doit \u00eatre certifi\u00e9 (une mini formation par le laboratoire). Le patient doit sign\u00e9 un accord de consentement au soin o\u00f9 il s&rsquo;engage en particulier \u00e0 suivre le plan de minimisation des risques. Ce PMR se focalise sur l&rsquo;\u00e9ventuelle h\u00e9patotoxicit\u00e9 de la mol\u00e9cule. La prescription se fait sur une ordonnance de m\u00e9dicament d&rsquo;exception et la prescription est hospitali\u00e8re. La d\u00e9livrance en officine prend entre 24 et 48 heures.<\/p>\n<p>Je rappelle que l&rsquo;effet secondaire majeur est la polyurie inh\u00e9rente au m\u00e9canisme d&rsquo;action de la mol\u00e9cule. Le blocage du r\u00e9cepteur V2 de l&rsquo;ADH entraine un diab\u00e8te insipide. Ces effets (syndrome polyuropolydipsique) peuvent \u00eatre minimis\u00e9s en suivant quelques r\u00e8gles hygi\u00e9nodi\u00e9t\u00e9tiques diminuant la charge osmotique.<\/p>\n<p>Je suis \u00e9mu de vivre ce moment qui voit arriver un m\u00e9dicament pour la prise en charge d&rsquo;une maladie g\u00e9n\u00e9tique. J&rsquo;esp\u00e8re que ce n&rsquo;est que le d\u00e9but d&rsquo;une belle histoire.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00c7a y est le premier traitement ralentissant la progression de la polykystose r\u00e9nale autosomique dominante est disponible en France. L&rsquo;arr\u00eat\u00e9 vient d&rsquo;\u00eatre publi\u00e9 au JO. Nous pourrons le prescrire d&rsquo;ici 4 jours. Il y a quelques contraintes. Le m\u00e9decin doit &hellip; <a href=\"https:\/\/perruchenautomne.eu\/wordpress\/2016\/07\/12\/jinarc-tolvaptan-officiellement-accessible-en-france\/\">Continuer la lecture <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1608,13,14],"tags":[1743,634,216,528],"class_list":["post-5045","post","type-post","status-publish","format-standard","hentry","category-kystes","category-medecine-2","category-nephrologie","tag-jinarc","tag-pkd","tag-polykystose-renale-autosomique-dominante","tag-tolvaptan"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p1l1zM-1jn","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/posts\/5045","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/comments?post=5045"}],"version-history":[{"count":1,"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/posts\/5045\/revisions"}],"predecessor-version":[{"id":5046,"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/posts\/5045\/revisions\/5046"}],"wp:attachment":[{"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/media?parent=5045"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/categories?post=5045"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/tags?post=5045"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}