{"id":6415,"date":"2023-03-04T14:37:33","date_gmt":"2023-03-04T13:37:33","guid":{"rendered":"https:\/\/perruchenautomne.eu\/wordpress\/?p=6415"},"modified":"2023-03-04T14:37:33","modified_gmt":"2023-03-04T13:37:33","slug":"ralentir-mon-vieillissement-cerebral","status":"publish","type":"post","link":"https:\/\/perruchenautomne.eu\/wordpress\/2023\/03\/04\/ralentir-mon-vieillissement-cerebral\/","title":{"rendered":"Ralentir mon vieillissement c\u00e9r\u00e9bral"},"content":{"rendered":"\n<p>Un article qui sera utile \u00e0 tous les n\u00e9phrologues quand nos coll\u00e8gues cardiologues nous demande si il faut en plus du c\u0153ur transplanter un rein. Il y a un b\u00e9n\u00e9fice sur la mortalit\u00e9 des patients \u00e0 partir de 40 ml\/mn\/1,73m<sup>2<\/sup>, de recevoir \u00e0 la fois un rein et un c\u0153ur que de ne recevoir qu&rsquo;un c\u0153ur. Le seul soucis est que le risque de perdre le transplant r\u00e9nal est le double dans le groupe double transplantation que transplantation r\u00e9nale simple. Si en terme individuel \u00e0 partir du stade 3b il y a un b\u00e9n\u00e9fice, en terme populationnel, le doublement du risque de perte du transplant r\u00e9nal pose une question d&rsquo;\u00e9quit\u00e9 importante pour les patients sur la liste d&rsquo;attente.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/1-s2.0-S0735109722076616-fx1.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"778\" height=\"501\" src=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/1-s2.0-S0735109722076616-fx1.jpg\" alt=\"\" class=\"wp-image-6416\" srcset=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/1-s2.0-S0735109722076616-fx1.jpg 778w, https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/1-s2.0-S0735109722076616-fx1-300x193.jpg 300w, https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/1-s2.0-S0735109722076616-fx1-768x495.jpg 768w\" sizes=\"auto, (max-width: 778px) 100vw, 778px\" \/><\/a><\/figure>\n\n\n\n<p>Un <a href=\"https:\/\/www.ajkd.org\/article\/S0272-6386(23)00003-3\/fulltext\">tr\u00e8s int\u00e9ressant papier<\/a> qui montre un lien entre la dysfonction endoth\u00e9liale et la diminution de la force musculaire chez le patient avec une maladie r\u00e9nale chronique.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-1.png\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"715\" src=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-1-1024x715.png\" alt=\"\" class=\"wp-image-6418\" srcset=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-1-1024x715.png 1024w, https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-1-300x209.png 300w, https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-1-768x536.png 768w, https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-1-1536x1072.png 1536w, https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-1-2048x1429.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<p>Horloge r\u00e9nale, un tr\u00e8s <a href=\"https:\/\/www.jci.org\/articles\/view\/167133#.ZAFj5Z1DmQM.twitter\">chouette papier<\/a> qui montre \u00e0 quel point les mammif\u00e8res sont rythmiques.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/167133-JCI-RG-RV-3_ga_659139.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"687\" height=\"1024\" src=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/167133-JCI-RG-RV-3_ga_659139-687x1024.jpg\" alt=\"\" class=\"wp-image-6419\" srcset=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/167133-JCI-RG-RV-3_ga_659139-687x1024.jpg 687w, https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/167133-JCI-RG-RV-3_ga_659139-201x300.jpg 201w, https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/167133-JCI-RG-RV-3_ga_659139.jpg 700w\" sizes=\"auto, (max-width: 687px) 100vw, 687px\" \/><\/a><\/figure>\n\n\n\n<p>Avoir une <a href=\"https:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/2801750?guestAccessKey=4212073d-4cf7-4fac-a9ea-5f9892084d5b&amp;utm_source=silverchair&amp;utm_campaign=jama_network&amp;utm_content=onc_weekly_highlights&amp;cmp=1&amp;utm_medium=email\">bonne sant\u00e9 cardiovasculaire<\/a> est associ\u00e9 \u00e0 une vie plus longue en bonne sant\u00e9. Ici la sant\u00e9 cardiovasculaire est mesur\u00e9 par le score LE8 et la vie en bonne sant\u00e9 par l&rsquo;absence de maladies cardiovasculaires, l&rsquo;absence de cancer, l&rsquo;absence de d\u00e9mence et l&rsquo;absence de diab\u00e8te. Le plus int\u00e9ressant est le b\u00e9n\u00e9fice d&rsquo;avoir une bonne sant\u00e9 cardiovasculaire est ind\u00e9pendant de ses revenus. Le gain de vie en bonne sant\u00e9 est de pr\u00e8s de 7 ans pour les hommes avec une tr\u00e8s bonne sant\u00e9 CV par rapport \u00e0 ceux avec une mauvaise qualit\u00e9 et pour les femmes le gain est de pr\u00e8s de 9 ans et demi.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-2.png\"><img loading=\"lazy\" decoding=\"async\" width=\"888\" height=\"445\" src=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-2.png\" alt=\"\" class=\"wp-image-6421\" srcset=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-2.png 888w, https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-2-300x150.png 300w, https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-2-768x385.png 768w\" sizes=\"auto, (max-width: 888px) 100vw, 888px\" \/><\/a><\/figure>\n\n\n\n<p>L&rsquo;hepcidine comme protecteur dans les maladies inflammatoires de l&rsquo;intestin. <a href=\"https:\/\/www.medecinesciences.org\/fr\/articles\/medsci\/full_html\/2021\/06\/msc200444\/msc200444.html?utm_source=email_alert_medsci&amp;utm_medium=email&amp;utm_campaign=2021-06-28#R11\">Un tr\u00e8s int\u00e9ressant article<\/a> en fran\u00e7ais qui montre que ne pas avoir d&rsquo;expression de l&rsquo;hepcidine n&rsquo;est pas une bonne id\u00e9e pour un bon \u00e9tat du tube digestif. Dans les situations \u00e0 risque de l\u00e9sions pour le tube digestif, il n&rsquo;est probablement pas bon de diminuer la quantit\u00e9 d&rsquo;hepcidine. Avant de prescrire un inhibiteur des prolyl hydroxylases, pensez y.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-5.png\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1019\" src=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-5-1024x1019.png\" alt=\"\" class=\"wp-image-6426\" srcset=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-5-1024x1019.png 1024w, https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-5-300x298.png 300w, https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-5-150x150.png 150w, https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-5-768x764.png 768w, https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-5.png 1131w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<p>Pour continuer dans les risques non pr\u00e9vus de faire joujou avec la voie HIFalpha par exemple avec des inhibiteurs des prolyl hydroxylases, ici un exemple dans le muscle. <a href=\"https:\/\/www.jci.org\/articles\/view\/161638\">L&rsquo;article<\/a> montre que maintenir une activit\u00e9 de la voie HIFalpha dans le muscle entra\u00eene un d\u00e9faut de r\u00e9g\u00e9n\u00e9ration musculaire. Je ne pourrai que conseiller d&rsquo;arr\u00eater cette classe th\u00e9rapeutique en cas de l\u00e9sion du muscle pour \u00e9viter que la r\u00e9g\u00e9n\u00e9ration ne prennent trop longtemps.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-6.png\"><img loading=\"lazy\" decoding=\"async\" width=\"875\" height=\"203\" src=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-6.png\" alt=\"\" class=\"wp-image-6427\" srcset=\"https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-6.png 875w, https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-6-300x70.png 300w, https:\/\/perruchenautomne.eu\/wordpress\/wp-content\/uploads\/2023\/03\/image-6-768x178.png 768w\" sizes=\"auto, (max-width: 875px) 100vw, 875px\" \/><\/a><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Un article qui sera utile \u00e0 tous les n\u00e9phrologues quand nos coll\u00e8gues cardiologues nous demande si il faut en plus du c\u0153ur transplanter un rein. Il y a un b\u00e9n\u00e9fice sur la mortalit\u00e9 des patients \u00e0 partir de 40 ml\/mn\/1,73m2, &hellip; <a href=\"https:\/\/perruchenautomne.eu\/wordpress\/2023\/03\/04\/ralentir-mon-vieillissement-cerebral\/\">Continuer la lecture <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[13,14],"tags":[2249,2251,2253,1958,2256,2255,2250,1959,2252,2254,740],"class_list":["post-6415","post","type-post","status-publish","format-standard","hentry","category-medecine-2","category-nephrologie","tag-double-transplantation-coeur-rein","tag-dysfonction-endotheliale","tag-hepcidine","tag-hif","tag-horloge","tag-le8","tag-muscle","tag-prolyl-hydroxylase","tag-regeneration","tag-sante-cardiovasculaire","tag-transplantation-renale"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p1l1zM-1Ft","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/posts\/6415","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/comments?post=6415"}],"version-history":[{"count":4,"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/posts\/6415\/revisions"}],"predecessor-version":[{"id":6428,"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/posts\/6415\/revisions\/6428"}],"wp:attachment":[{"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/media?parent=6415"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/categories?post=6415"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/perruchenautomne.eu\/wordpress\/wp-json\/wp\/v2\/tags?post=6415"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}